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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIRA All Species: 13.94
Human Site: S498 Identified Species: 19.17
UniProt: P54198 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54198 NP_003316.3 1017 111835 S498 T M L S S H S S P Q L L P L D
Chimpanzee Pan troglodytes XP_001165585 1017 111787 S498 T M L S S H S S P Q L L P L D
Rhesus Macaque Macaca mulatta XP_001112873 1138 124408 S619 T M L S S H S S P Q L L P L D
Dog Lupus familis XP_543550 1017 111618 N498 T M L S S H S N P Q L L P L D
Cat Felis silvestris
Mouse Mus musculus Q61666 1015 111748 G498 T M L S S P S G Q Q L L P L D
Rat Rattus norvegicus NP_001129232 1015 111665 G498 T M L S S P S G Q Q L L P L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P79987 1019 112055 S498 T L A G S I M S S Q N N Q Q L
Frog Xenopus laevis Q8QFR2 1013 112021 N498 S M M S S Q S N Q Q L I S L D
Zebra Danio Brachydanio rerio XP_696478 1010 111223 I498 S T Q L T P Q I S S D S N T A
Tiger Blowfish Takifugu rubipres O42611 1025 111838 T498 S S M S N Q L T S Q L S S D S
Fruit Fly Dros. melanogaster O17468 1047 113397 L495 P L M P L E P L V S K I D L G
Honey Bee Apis mellifera XP_001122939 838 91355 S344 A A C S W D G S V V L I E F T
Nematode Worm Caenorhab. elegans Q09589 935 103412 E441 I Q L T K S M E D N S K E N E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q32SG6 964 105548 K470 P T A D D V K K G N Q L S S P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LXN4 1051 115544 G498 E N N I M I N G E S H N F L P
Baker's Yeast Sacchar. cerevisiae P32479 840 93871 R346 V W S T S R P R P I L V A F D
Red Bread Mold Neurospora crassa Q7RZI0 1035 112420 K496 V T I T K D G K K R V A P L L
Conservation
Percent
Protein Identity: 100 99.9 88.4 96.5 N.A. 95.7 95.5 N.A. N.A. 86 78 69.8 67.7 31.1 40 26.5 N.A.
Protein Similarity: 100 99.9 88.9 98 N.A. 97.5 97.7 N.A. N.A. 93.1 88.5 83.2 81.3 48 55.1 46.1 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 80 80 N.A. N.A. 26.6 53.3 0 20 6.6 20 6.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 80 80 N.A. N.A. 33.3 80 13.3 46.6 26.6 26.6 20 N.A.
Percent
Protein Identity: N.A. 25.6 N.A. 25 22.4 25.9
Protein Similarity: N.A. 43.7 N.A. 43.3 41.2 45.8
P-Site Identity: N.A. 6.6 N.A. 6.6 26.6 13.3
P-Site Similarity: N.A. 6.6 N.A. 13.3 40 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 6 12 0 0 0 0 0 0 0 0 6 6 0 6 % A
% Cys: 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 6 6 12 0 0 6 0 6 0 6 6 48 % D
% Glu: 6 0 0 0 0 6 0 6 6 0 0 0 12 0 6 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 6 12 0 % F
% Gly: 0 0 0 6 0 0 12 18 6 0 0 0 0 0 6 % G
% His: 0 0 0 0 0 24 0 0 0 0 6 0 0 0 0 % H
% Ile: 6 0 6 6 0 12 0 6 0 6 0 18 0 0 0 % I
% Lys: 0 0 0 0 12 0 6 12 6 0 6 6 0 0 0 % K
% Leu: 0 12 42 6 6 0 6 6 0 0 59 42 0 59 12 % L
% Met: 0 42 18 0 6 0 12 0 0 0 0 0 0 0 0 % M
% Asn: 0 6 6 0 6 0 6 12 0 12 6 12 6 6 0 % N
% Pro: 12 0 0 6 0 18 12 0 30 0 0 0 42 0 12 % P
% Gln: 0 6 6 0 0 12 6 0 18 53 6 0 6 6 0 % Q
% Arg: 0 0 0 0 0 6 0 6 0 6 0 0 0 0 0 % R
% Ser: 18 6 6 53 53 6 42 30 18 18 6 12 18 6 6 % S
% Thr: 42 18 0 18 6 0 0 6 0 0 0 0 0 6 6 % T
% Val: 12 0 0 0 0 6 0 0 12 6 6 6 0 0 0 % V
% Trp: 0 6 0 0 6 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _